Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | PHGDH | O43175 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 6/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14433874 | 0.76 | F2 (0.48) | PHGDHMGLLALDH1A1MEN1KMT2A | |
| SCHEMBL10274470 | 0.75 | NPC1 (0.74) | NPC1ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL25824843 | 0.75 | NPC1 (0.47) | NPC1PHGDHMGLLALDH1A1MEN1 | |
| SCHEMBL14434063 | 0.74 | MGLL (0.41) | NPC1PHGDHMGLLALDH1A1CYP1A2 | |
| SCHEMBL21131463 | 0.73 | PHGDH (0.44) | NPC1PHGDHMGLLALDH1A1MEN1 | |
| SCHEMBL349335 | 0.73 | F2 (0.50) | NPC1PHGDHMGLLALDH1A1MEN1 | |
| SCHEMBL9061263 | 0.73 | F2 (0.50) | NPC1PHGDHMGLLALDH1A1MEN1 | |
| SCHEMBL14434111 | 0.72 | HSD11B1 (0.39) | ALDH1A1HPGDMAPTCYP1A2CYP2C9 | |
| SCHEMBL14433876 | 0.72 | HTT (0.42) | PHGDHMGLLALDH1A1POLBRECQL | |
| SCHEMBL24052080 | 0.72 | PHGDH (0.50) | NPC1PHGDHMGLLALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007087204-A2 | HETEROCYCLES AS NICOTINIC ACID RECEPTOR AGONISTS FOR THE TREATMENT OF DYYSLIPIDEMIA | SCHERING CORPOORATION (US) | 2007-08-02 | — | — | WO | disclosed |