Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Isoetharine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 7/20 | 0.97 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.97 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.97 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.84 |
| ▸ | MAPT | P10636 | 7/20 | 0.84 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.84 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.84 |
| ▸ | TSHR | P16473 | 4/20 | 0.84 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.84 |
| ▸ | LMNA | P02545 | 4/20 | 0.84 |
| ▸ | BLM | P54132 | 4/20 | 0.84 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.84 |
| ▸ | GAA | P10253 | 3/20 | 0.84 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.84 |
| ▸ | THPO | P40225 | 2/20 | 0.84 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.84 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.84 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.84 |
| ▸ | HTT | P42858 | 1/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isoetharine SCHEMBL56515 | 0.98 | ADRB2 (1.00) | ADRB2PTGS2OPRK1SLC6A3KDM4E | |
| Isoetharine SCHEMBL29515330 | 0.98 | ADRB2 (1.00) | ADRB2PTGS2OPRK1SLC6A3KDM4E | |
| Isoetharine SCHEMBL21252711 | 0.98 | ADRB2 (1.00) | ADRB2PTGS2OPRK1SLC6A3KDM4E | |
| Isoetharine SCHEMBL56516 | 0.98 | ADRB2 (1.00) | ADRB2PTGS2OPRK1SLC6A3KDM4E | |
| Isoetharine SCHEMBL3218412 | 0.98 | ADRB2 (1.00) | ADRB2PTGS2OPRK1SLC6A3KDM4E | |
| Isoetharine SCHEMBL3225540 | 0.98 | ADRB2 (1.00) | ADRB2PTGS2OPRK1SLC6A3KDM4E | |
| Isoetharine SCHEMBL4377543 | 0.93 | KDM4E (0.97) | ADRB2PTGS2OPRK1SLC6A3KDM4E | |
| Isoetharine SCHEMBL2407556 | 0.91 | KDM4E (1.00) | ADRB2PTGS2OPRK1SLC6A3KDM4E | |
| Isoetharine SCHEMBL212005 | 0.91 | KDM4E (1.00) | ADRB2PTGS2OPRK1SLC6A3KDM4E | |
| Isoetharine SCHEMBL29380912 | 0.91 | KDM4E (1.00) | ADRB2PTGS2OPRK1SLC6A3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1041 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240123168-A1 | PRODUCT DELIVERY DEVICES AND METHODS | MUSTAPHA JIHAD A (US) | 2024-04-18 | — | — | US | claimed |
| EP-4255390-A1 | COMPOSITIONS, DEVICES, AND METHODS FOR TREATING RESPIRATORY DISORDERS | Breathe Restore, Inc. (US) | 2023-10-11 | — | — | EP | claimed |
| EP-4255541-A1 | PRODUCT DELIVERY DEVICES AND METHODS | Breathe Restore, Inc. (US) | 2023-10-11 | — | — | EP | claimed |
| US-20230181847-A1 | PRODUCT DELIVERY DEVICES AND METHODS | BREATHE RESTORE INC (US) | 2023-06-15 | — | — | US | claimed |
| US-11672929-B2 | Product delivery devices and methods | BREATHE RESTORE, INC. (US) | 2023-06-13 | — | — | US | claimed |
| US-20220270733-A1 | SYSTEMS AND METHODS FOR DETERMINING COMPLIANCE AND EFFICACY OF A DOSING REGIMEN FOR A PHARMACEUTICAL AGENT | SUMNER BLUFFS LLC (US) | 2022-08-25 | — | — | US | claimed |
| US-20220262507-A1 | PHARMACEUTICAL AND BIOLOGICAL AGENT DELIVERY SYSTEM HAVING BIOMETRIC DATA ACQUISITION AND MONITORING CAPABILITIES | SUMNER BLUFFS LLC (US) | 2022-08-18 | — | — | US | claimed |
| US-20220246263-A1 | NEBULIZING DEVICES AND SYSTEMS HAVING BIOMETRIC DATA ACQUISITION AND MONITORING CAPABILITIES | SUMNER BLUFFS LLC (US) | 2022-08-04 | — | — | US | claimed |
| WO-2022118225-A1 | PRODUCT DELIVERY DEVICES AND METHODS | BREATHE RESTORE, INC. (US) | 2022-06-09 | — | — | WO | claimed |
| WO-2022118220-A1 | COMPOSITIONS, DEVICES, AND METHODS FOR TREATING RESPIRATORY DISORDERS | BREATHE RESTORE, INC. (US) | 2022-06-09 | — | — | WO | claimed |
| WO-2001093846-A2 | METHOD FOR TREATING RESPIRATORY DISORDERS ASSOCIATED WITH PULMONARY ELASTIC FIBER INJURY COMPRISING THE USE OF CLYCOSAMINOGLYCANS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2001-12-13 | — | — | WO | claimed |
| EP-1119345-A1 | ENCAPSULATION OF SENSITIVE LIQUID COMPONENTS INTO A MATRIX TO OBTAIN DISCRETE SHELF-STABLE PARTICLES | GENERAL MILLS, INC. (US) | 2001-08-01 | — | — | EP | claimed |
| WO-2000021504-A1 | ENCAPSULATION OF SENSITIVE LIQUID COMPONENTS INTO A MATRIX TO OBTAIN DISCRETE SHELF-STABLE PARTICLES | GENERAL MILLS, INC. (US) | 2000-04-20 | — | — | WO | claimed |
| EP-0935523-A4 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | GEN MILLS INC (US) | 1999-12-29 | — | — | EP | claimed |
| EP-0935523-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | GENERAL MILLS, INC. (US) | 1999-08-18 | — | — | EP | claimed |
| WO-1998018610-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | LENGERICH BERNHARD H VAN (US) | 1998-05-07 | — | — | WO | claimed |
| EP-0527940-A1 | DIRECT SPRAY-DRIED DRUG/LIPID POWDER COMPOSITION | LIPOSOME TECHNOLOGY, INC. (US) | 1993-02-24 | — | — | EP | claimed |
| WO-1991016882-A1 | DIRECT SPRAY-DRIED DRUG/LIPID POWDER COMPOSITION | LIPOSOME TECHNOLOGY, INC. (US) | 1991-11-14 | — | — | WO | claimed |
| EP-0351897-A2 | Skin penetration system for salts of amine-functional drugs | THE PROCTER & GAMBLE COMPANY (US) | 1990-01-24 | — | — | EP | claimed |
| US-4895719-A | SUSPENSION, ENCAPSULATION, DRUG DELIVERY | LIPOSOME TECHNOLOGY, INC. (US) | 1990-01-23 | — | — | US | claimed |