Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Isoetharine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 6/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 1.00 |
| ▸ | MAPT | P10636 | 6/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | TSHR | P16473 | 4/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 3/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 3/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 3/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 3/20 | 1.00 |
| ▸ | BLM | P54132 | 2/20 | 1.00 |
| ▸ | THPO | P40225 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 1.00 |
| ▸ | HTT | P42858 | 1/20 | 1.00 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isoetharine SCHEMBL2407556 | 1.00 | KDM4E (1.00) | KDM4EADRB2MAPTHIF1ALMNA | |
| Isoetharine SCHEMBL29380912 | 1.00 | KDM4E (1.00) | KDM4EADRB2MAPTHIF1ALMNA | |
| Isoetharine SCHEMBL4377543 | 0.99 | KDM4E (0.97) | KDM4EADRB2MAPTHIF1ALMNA | |
| Isoetharine SCHEMBL3218412 | 0.93 | ADRB2 (1.00) | KDM4EADRB2MAPTHIF1ALMNA | |
| Isoetharine SCHEMBL29515330 | 0.93 | ADRB2 (1.00) | KDM4EADRB2MAPTHIF1ALMNA | |
| Isoetharine SCHEMBL56516 | 0.93 | ADRB2 (1.00) | KDM4EADRB2MAPTHIF1ALMNA | |
| Isoetharine SCHEMBL56515 | 0.93 | ADRB2 (1.00) | KDM4EADRB2MAPTHIF1ALMNA | |
| Isoetharine SCHEMBL3225540 | 0.93 | ADRB2 (1.00) | KDM4EADRB2MAPTHIF1ALMNA | |
| Isoetharine SCHEMBL21252711 | 0.93 | ADRB2 (1.00) | KDM4EADRB2MAPTHIF1ALMNA | |
| Isoetharine SCHEMBL211343 | 0.91 | ADRB2 (0.97) | KDM4EADRB2MAPTHIF1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 862 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104825397-A | Controlled release delivery device containing organosol coating | ISA ODIDI | 2015-08-12 | — | — | CN | claimed |
| CN-102741396-A | Small molecules to support growth of pluripotent cells and methods thereof | VIACYTE INC | 2012-10-17 | — | — | CN | claimed |
| US-7550466-B2 | Alpha and/or β-adrenergic antagonists and agonists to treat pain | SUN HEALTH RESEARCH INSTITUTE (US) | 2009-06-23 | — | — | US | claimed |
| CN-101453993-A | Controlled release delivery device containing organosol coating | ISA ODIDI (CA) | 2009-06-10 | — | — | CN | claimed |
| EP-2007360-A1 | CONTROLLED RELEASE DELIVERY DEVICE COMPRISING AN ORGANOSOL COAT | Odidi, Isa (CA) | 2008-12-31 | — | — | EP | claimed |
| US-7462618-B2 | Treatment of inflammatory autoimmune diseases with alpha-adrenergic antagonists and beta-adrenergic agonists | SUN HEALTH RESEARCH INSTITUTE (US) | 2008-12-09 | — | — | US | claimed |
| US-20080153830-A1 | ALPHA AND/OR BETA-ADRENERGIC ANTAGONISTS AND AGONISTS TO TREAT PAIN | SUN HEALTH RESEARCH INSTITUTE | 2008-06-26 | — | — | US | claimed |
| WO-2007112581-A1 | CONTROLLED RELEASE DELIVERY DEVICE COMPRISING AN ORGANOSOL COAT | ODIDI ISA (CA) | 2007-10-11 | — | — | WO | claimed |
| US-20050049256-A1 | Treatment of inflammatory autoimmune diseases with alpha-adrenergic antagonists and beta-adrenergic agonists | SUN HEALTH RESEARCH INSTITUTE | 2005-03-03 | — | — | US | claimed |
| EP-1292314-A2 | METHOD FOR TREATING RESPIRATORY DISORDERS ASSOCIATED WITH PULMONARY ELASTIC FIBER INJURY COMPRISING THE USE OF GLYCOSAMINOGLYCANS | The Trustees of Columbia University in the City of New York (US) | 2003-03-19 | — | — | EP | claimed |
| US-20020086852-A1 | Method for treating respiratory disorders associated with pulmonary elastic fiber injury | TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE | 2002-07-04 | — | — | US | claimed |
| WO-2001093846-A2 | METHOD FOR TREATING RESPIRATORY DISORDERS ASSOCIATED WITH PULMONARY ELASTIC FIBER INJURY COMPRISING THE USE OF CLYCOSAMINOGLYCANS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2001-12-13 | — | — | WO | claimed |
| EP-0527940-A1 | DIRECT SPRAY-DRIED DRUG/LIPID POWDER COMPOSITION | LIPOSOME TECHNOLOGY, INC. (US) | 1993-02-24 | — | — | EP | claimed |
| WO-1991016882-A1 | DIRECT SPRAY-DRIED DRUG/LIPID POWDER COMPOSITION | LIPOSOME TECHNOLOGY, INC. (US) | 1991-11-14 | — | — | WO | claimed |
| US-4895719-A | SUSPENSION, ENCAPSULATION, DRUG DELIVERY | LIPOSOME TECHNOLOGY, INC. (US) | 1990-01-23 | — | — | US | claimed |
| EP-4714407-A2 | DEVICES TO PROVIDE HANDS FREE SCLERAL DEPRESSION DURING OPHTHALMIC PROCEDURES | Alcon Inc. (CH) | 2026-03-25 | — | — | EP | disclosed |
| EP-3157408-B1 | DEVICES TO PROVIDE HANDS FREE SCLERAL DEPRESSION DURING OPHTHALMIC PROCEDURES | ALCON INC (CH) | 2026-03-25 | — | — | EP | disclosed |
| EP-0163227-A1 | 5-Substituted chromones and thiochromones | MILES INC. (US) | 1985-12-04 | — | — | EP | disclosed |
| US-4484577-A | Drug delivery method and inhalation device therefor | KEY PHARMACEUTICALS, INC. (US) | 1984-11-27 | — | — | US | disclosed |
| EP-0098041-A2 | Sesquiterpene lactones, extracts containing them, their preparation and pharmaceutical use | R.P. SCHERER CORPORATION (US) | 1984-01-11 | — | — | EP | disclosed |