Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 4/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | CKS1B | P61024 | 1/20 | 0.35 |
| ▸ | SKP1 | P63208 | 1/20 | 0.35 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 3/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2600836 | 1.00 | KMT2A (0.41) | KMT2AL3MBTL1KDM1AMAOBEPHX2 | |
| SCHEMBL2600838 | 1.00 | KMT2A (0.41) | KMT2AL3MBTL1KDM1AMAOBEPHX2 | |
| SCHEMBL2600837 | 1.00 | KMT2A (0.41) | KMT2AL3MBTL1KDM1AMAOBEPHX2 | |
| SCHEMBL2600839 | 0.84 | NOS1 (0.38) | KMT2AL3MBTL1KDM1AMAOBEPHX2 | |
| SCHEMBL12385615 | 0.82 | CCR2 (0.37) | KMT2AL3MBTL1CCR2SIRT1TGFBR1 | |
| SCHEMBL2600835 | 0.81 | KMT2A (0.39) | KMT2AL3MBTL1KDM1AMAOBEPHX2 | |
| SCHEMBL2114654 | 0.81 | KMT2A (0.39) | KMT2AL3MBTL1KDM1AMAOBEPHX2 | |
| SCHEMBL2600825 | 0.81 | CCR2 (0.36) | RENCCR2 | |
| SCHEMBL2600822 | 0.81 | CCR2 (0.36) | RENCCR2 | |
| SCHEMBL2113649 | 0.81 | CCR2 (0.36) | RENCCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158658-B2 | Heteroaromatic selective inhibitors of neuronal nitric oxide synthase | NORTHWESTERN UNIVERSITY (US) | 2012-04-17 | — | — | US | disclosed |
| US-7994326-B2 | For treatment of various forms of neurodegeneration, including that from stroke, Alzheimer's disease, Parkinson's disease, and Huntington's disease | NORTHWESTERN UNIVERSITY (US) | 2011-08-09 | — | — | US | disclosed |