Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 19/20 | 0.69 |
| ▸ | SPR | P35270 | 2/20 | 0.67 |
| ▸ | INSR | P06213 | 2/20 | 0.66 |
| ▸ | LCK | P06239 | 2/20 | 0.66 |
| ▸ | LTK | P29376 | 2/20 | 0.66 |
| ▸ | AXL | P30530 | 2/20 | 0.66 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.66 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.66 |
| ▸ | MERTK | Q12866 | 2/20 | 0.66 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.66 |
| ▸ | FLT3 | P36888 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21135589 | 0.88 | ALK (0.88) | ALKSPRINSRLCKLTK | |
| SCHEMBL23915691 | 0.88 | ALK (0.88) | ALKSPRINSRLCKLTK | |
| SCHEMBL21759921 | 0.81 | ALK (1.00) | ALKSPRINSRLCKLTK | |
| SCHEMBL24046489 | 0.81 | ALK (1.00) | ALKSPRINSRLCKLTK | |
| SCHEMBL10270586 | 0.81 | ALK (0.85) | ALKSPRINSRLCKLTK | |
| SCHEMBL10270812 | 0.80 | SPR (1.00) | ALKSPRINSRLCKLTK | |
| SCHEMBL23810096 | 0.80 | ALK (0.90) | ALKINSRLCKLTKAXL | |
| SCHEMBL23810121 | 0.80 | ALK (0.90) | ALKINSRLCKLTKAXL | |
| SCHEMBL10270232 | 0.80 | ALK (0.85) | ALKSPRINSRLCKLTK | |
| SCHEMBL15192876 | 0.80 | ALK (0.85) | ALKSPRINSRLCKLTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019113071-A1 | COMPOSITIONS AND METHODS FOR TREATING ALK-MEDIATED CANCER | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2019-06-13 | — | — | WO | disclosed |