SCHEMBL21136309

SCHEMBL21136309

CNc1cccc2c1C(=O)N(C(CCC=O)C(N)=O)C2=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
POLB P06746 2/20 0.41
MAPT P10636 2/20 0.38
MAPK1 P28482 2/20 0.38
EGFR P00533 1/20 0.38
PABPC1 P11940 1/20 0.38
RAB9A P51151 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
HPGD P15428 3/20 0.37
PDE4A P27815 5/20 0.36
PDE4B Q07343 5/20 0.36
PDE4C Q08493 5/20 0.36
PDE4D Q08499 5/20 0.36
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
TNF P01375 2/20 0.35
KDM4E B2RXH2 3/20 0.34
USP2 O75604 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6262312 0.85 ALDH1A1 (0.52) ALDH1A1L3MBTL1POLBMAPTMAPK1
SCHEMBL23128980 0.84 ALDH1A1 (0.46) ALDH1A1L3MBTL1POLBMAPTMAPK1
SCHEMBL21308302 0.84 ALDH1A1 (0.46) ALDH1A1L3MBTL1POLBMAPTMAPK1
SCHEMBL12811074 0.84 ALDH1A1 (0.40) ALDH1A1L3MBTL1POLBMAPK1HPGD
SCHEMBL21308307 0.84 ALDH1A1 (0.43) ALDH1A1L3MBTL1POLBMAPK1HPGD
SCHEMBL17884698 0.83 ALDH1A1 (0.45) ALDH1A1L3MBTL1POLBMAPTMAPK1
SCHEMBL24326937 0.83 ALDH1A1 (0.42) ALDH1A1L3MBTL1POLBMAPK1HPGD
SCHEMBL6256204 0.82 ALDH1A1 (0.47) ALDH1A1L3MBTL1POLBMAPTMAPK1
SCHEMBL20046786 0.82 ALDH1A1 (0.44) ALDH1A1L3MBTL1POLBMAPTMAPK1
SCHEMBL21308118 0.82 TNF (0.44) ALDH1A1L3MBTL1POLBMAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019113071-A1 COMPOSITIONS AND METHODS FOR TREATING ALK-MEDIATED CANCER ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) 2019-06-13 WO disclosed