Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | MET | P08581 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CKS1B | P61024 | 1/20 | 0.36 |
| ▸ | SKP1 | P63208 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21136903 | 0.87 | ALDH1A1 (0.40) | KCNH2MAPTALDH1A1LMNAMET | |
| SCHEMBL28681459 | 0.87 | KCNH2 (0.38) | KCNH2MAPTALDH1A1LMNAMET | |
| SCHEMBL16636900 | 0.85 | MAPK8 (0.39) | KCNH2MAPTSMN1; SMN2MAPK8GPR119 | |
| SCHEMBL30998001 | 0.85 | MAPT (0.46) | KCNH2MAPTALDH1A1LMNAMET | |
| SCHEMBL27094352 | 0.85 | MAPT (0.46) | KCNH2MAPTALDH1A1LMNAMET | |
| SCHEMBL21099594 | 0.85 | KCNH2 (0.37) | KCNH2MAPTALDH1A1LMNAMET | |
| SCHEMBL28648177 | 0.85 | KCNH2 (0.37) | KCNH2MAPTALDH1A1LMNAMET | |
| SCHEMBL21099600 | 0.85 | KCNH2 (0.37) | KCNH2MAPTALDH1A1LMNAMET | |
| SCHEMBL21136780 | 0.85 | KCNH2 (0.37) | KCNH2MAPTALDH1A1LMNAMET | |
| SCHEMBL16636974 | 0.85 | MAPK8 (0.39) | KCNH2MAPTSMN1; SMN2MAPK8GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019110751-A1 | TETRACYCLIC COMPOUNDS AS INHIBITORS OF G12C MUTANT RAS PROTEIN, FOR USE AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2019-06-13 | — | — | WO | disclosed |