Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | MET | P08581 | 2/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CKS1B | P61024 | 2/20 | 0.38 |
| ▸ | SKP1 | P63208 | 2/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30998001 | 1.00 | MAPT (0.46) | MAPTALDH1A1LMNAKCNH2MET | |
| SCHEMBL21136735 | 0.85 | KCNH2 (0.47) | MAPTALDH1A1LMNAKCNH2MET | |
| SCHEMBL27094365 | 0.85 | MAP4K4 (0.42) | MAPTALDH1A1LMNAKCNH2GPR119 | |
| SCHEMBL27094367 | 0.85 | ABL1 (0.38) | MAPTALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL29889650 | 0.80 | UCHL1 (0.33) | MAPTALDH1A1LMNAKCNH2MET | |
| SCHEMBL21136775 | 0.77 | MET (0.47) | MAPTALDH1A1LMNAKCNH2MET | |
| SCHEMBL21136848 | 0.74 | MET (0.47) | MAPTALDH1A1LMNAKCNH2MET | |
| SCHEMBL29153252 | 0.73 | PRKCQ (0.36) | MAPTALDH1A1LMNAMETGPR119 | |
| SCHEMBL15770114 | 0.73 | ALDH1A1 (0.53) | MAPTALDH1A1LMNAKCNH2MET | |
| SCHEMBL21137338 | 0.73 | KCNH2 (0.38) | MAPTALDH1A1LMNAKCNH2MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4322945-A2 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2024-02-21 | — | — | EP | disclosed |
| WO-2022221528-A2 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-10-20 | — | — | WO | disclosed |