Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 4/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | ADA | P00813 | 1/20 | 0.41 |
| ▸ | SLC29A1 | Q99808 | 7/20 | 0.40 |
| ▸ | PGK1 | P00558 | 1/20 | 0.39 |
| ▸ | PGK2 | P07205 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NT5E | P21589 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18061805 | 1.00 | ADORA2A (0.46) | ADORA2ACYP2C19ADORA3ADORA1ADA | |
| SCHEMBL18061771 | 1.00 | ADORA2A (0.46) | ADORA2ACYP2C19ADORA3ADORA1ADA | |
| SCHEMBL18061773 | 0.90 | ADORA2A (0.44) | ADORA2ACYP2C19ADORA3ADORA1ADA | |
| SCHEMBL18061807 | 0.90 | ADORA2A (0.44) | ADORA2ACYP2C19ADORA3ADORA1ADA | |
| SCHEMBL19644820 | 0.90 | NT5E (0.42) | ADORA2ACYP2C19ADORA3ADORA1ADA | |
| SCHEMBL19644811 | 0.89 | ADORA2A (0.52) | ADORA2AADORA3ADORA1LMNANT5E | |
| SCHEMBL19644812 | 0.89 | ADORA2A (0.41) | ADORA2ACYP2C19ADORA3ADORA1ADA | |
| SCHEMBL21136341 | 0.88 | ADORA2A (0.44) | ADORA2ACYP2C19ADORA3ADORA1ADA | |
| SCHEMBL23760819 | 0.88 | NT5E (0.38) | ADORA2ACYP2C19ADORA3ADORA1NT5E | |
| SCHEMBL9569321 | 0.87 | ADORA2A (0.49) | ADORA2ACYP2C19ADORA3ADORA1ADA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10946033-B2 | 2′-substituted-N6-substituted purine nucleotides for RNA virus treatment | Atea Pharmaceuticals, Inc. (US) | 2021-03-16 | — | — | US | disclosed |
| US-20190201433-A1 | 2'-SUBSTITUTED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR RNA VIRUS TREATMENT | Atea Pharmaceuticals, Inc. (US) | 2019-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10946033-B2 | 2′-substituted-N6-substituted purine nucleotides for RNA virus treatment | NSUN2, ADAR, NSUN3 | ADORA2A 32/4885CYP2C19 4355/4885ADORA3 67/4885 |
| US-20190201433-A1 | 2'-SUBSTITUTED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR RNA VIRUS TREATMENT | NSUN2, ADAR, NSUN3 | ADORA2A 31/4885CYP2C19 4370/4885ADORA3 59/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.