Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.36 |
| ▸ | MMP1 | P03956 | 2/20 | 0.35 |
| ▸ | MMP9 | P14780 | 2/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCND3 | P30281 | 1/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21099347 | 0.86 | KCNH2 (0.38) | GPR119MMP1MMP9MMP3MMP7 | |
| SCHEMBL21100018 | 0.76 | PIK3CD (0.36) | GPR119MMP1MMP9MMP3MMP7 | |
| SCHEMBL21100052 | 0.75 | GPR119 (0.39) | GPR119PIK3CDHDAC8HDAC6 | |
| SCHEMBL21099357 | 0.75 | GPR119 (0.38) | GPR119PIK3CDHDAC8HDAC6 | |
| SCHEMBL21099308 | 0.74 | KCNH2 (0.38) | GPR119MMP1MMP9MMP3MMP7 | |
| SCHEMBL21137090 | 0.74 | KCNH2 (0.38) | GPR119MMP1MMP9MMP3MMP7 | |
| SCHEMBL21137118 | 0.70 | KCNH2 (0.40) | GPR119CCND3CDK6 | |
| SCHEMBL21137563 | 0.70 | CKS1B (0.38) | GPR119 | |
| SCHEMBL21099343 | 0.69 | KCNH2 (0.38) | GPR119MMP1MMP9MMP3MMP7 | |
| SCHEMBL28648177 | 0.68 | KCNH2 (0.37) | GPR119MMP1MMP9MMP3MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019110751-A1 | TETRACYCLIC COMPOUNDS AS INHIBITORS OF G12C MUTANT RAS PROTEIN, FOR USE AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2019-06-13 | — | — | WO | disclosed |