Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 2/20 | 0.38 |
| ▸ | SKP1 | P63208 | 2/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21137118 | 0.83 | KCNH2 (0.40) | CKS1BSKP1SKP2KCNH2GPR119 | |
| SCHEMBL21137536 | 0.81 | KRAS (0.38) | CKS1BSKP1SKP2GPR119MAP4K4 | |
| SCHEMBL21137486 | 0.77 | NR1H2 (0.37) | CKS1BSKP1SKP2KCNH2GPR119 | |
| SCHEMBL21137524 | 0.77 | GPR119 (0.38) | CKS1BSKP1SKP2KCNH2GPR119 | |
| SCHEMBL21100052 | 0.70 | GPR119 (0.39) | GPR119 | |
| SCHEMBL21137362 | 0.70 | GPR119 (0.36) | GPR119 | |
| SCHEMBL21136818 | 0.69 | KCNH2 (0.40) | CKS1BSKP1SKP2KCNH2GPR119 | |
| SCHEMBL21099357 | 0.69 | GPR119 (0.38) | GPR119 | |
| SCHEMBL30899646 | 0.66 | CKS1B (0.60) | CKS1BSKP1SKP2GPR119MAP4K4 | |
| SCHEMBL30365856 | 0.66 | CKS1B (0.60) | CKS1BSKP1SKP2GPR119MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019110751-A1 | TETRACYCLIC COMPOUNDS AS INHIBITORS OF G12C MUTANT RAS PROTEIN, FOR USE AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2019-06-13 | — | — | WO | disclosed |