Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 6/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.52 |
| ▸ | CLK2 | P49760 | 2/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.51 |
| ▸ | BLK | P51451 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
| ▸ | STK3 | Q13188 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 8/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | ITK | Q08881 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 2/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | EEF2K | O00418 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL877704 | 0.94 | ROCK2 (0.54) | ROCK2ROCK1CLK2AURKBCLK4 | |
| SCHEMBL877230 | 0.89 | ROCK2 (0.65) | ROCK2ROCK1CLK2AURKBCLK4 | |
| SCHEMBL30915546 | 0.89 | ROCK2 (0.65) | ROCK2ROCK1CLK2AURKBCLK4 | |
| SCHEMBL30915545 | 0.89 | ROCK2 (0.65) | ROCK2ROCK1CLK2AURKBCLK4 | |
| SCHEMBL878289 | 0.89 | ROCK2 (0.53) | ROCK2ROCK1CLK2AURKBCLK4 | |
| SCHEMBL876815 | 0.88 | ROCK2 (0.54) | ROCK2ROCK1CLK2AURKBCLK4 | |
| SCHEMBL3795123 | 0.87 | ROCK2 (0.55) | ROCK2ROCK1CLK2AURKBCLK4 | |
| SCHEMBL877337 | 0.87 | ROCK2 (0.62) | ROCK2ROCK1CLK2AURKBCLK4 | |
| SCHEMBL3794704 | 0.85 | ROCK2 (0.48) | ROCK2ROCK1CLK2AURKBCLK4 | |
| SCHEMBL877451 | 0.85 | ABCG2 (0.55) | ROCK2ABCG2ABCB1EGFRITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190177311-A1 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | SURFACE LOGIX, INC. | 2019-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190177311-A1 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | ROCK2, ROCK1, RHOT2 | ROCK2 1/4885ROCK1 2/4885CLK2 1983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.