Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 7/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27771394 | 0.81 | KDM4C (0.43) | KDM4CSLC6A4SLC6A2SLC6A3DRD2 | |
| SCHEMBL7149460 | 0.81 | CCR3 (0.46) | KDM4CMAPK14HTR6CCR3 | |
| SCHEMBL1865494 | 0.81 | PRKCI (0.45) | KDM4CSLC6A4SLC6A2SLC6A3DRD2 | |
| SCHEMBL20135460 | 0.81 | KDM4C (0.43) | KDM4CSLC6A4SLC6A2SLC6A3DRD2 | |
| SCHEMBL4676971 | 0.81 | SCD (0.45) | KDM4CSLC6A4SLC6A2SLC6A3HTR6 | |
| SCHEMBL4996021 | 0.79 | KDM4C (0.44) | KDM4CSLC6A4SLC6A2SLC6A3BRD4 | |
| SCHEMBL24124024 | 0.78 | KDM4C (0.41) | KDM4CSLC6A4SLC6A2SLC6A3DRD2 | |
| SCHEMBL21671819 | 0.78 | KDM4C (0.41) | KDM4CSLC6A4SLC6A2SLC6A3DRD2 | |
| SCHEMBL25675824 | 0.78 | KDM4C (0.43) | KDM4CSLC6A4SLC6A2SLC6A3DRD2 | |
| SCHEMBL1239171 | 0.77 | DRD2 (0.55) | KDM4CSLC6A4DRD2HTR6OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190185455-A1 | Substituted Pyrrolidine Amides I | GRUENENTHAL GMBH (DE) | 2019-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190185455-A1 | Substituted Pyrrolidine Amides I | NR3C1, NR3C2, NR5A1 | KDM4C 3719/4885SLC6A4 2805/4885SLC6A2 2407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.