Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.62 |
| ▸ | TACR3 | P29371 | 2/20 | 0.59 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.51 |
| ▸ | SPR | P35270 | 1/20 | 0.50 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.49 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CCR3 | P51677 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1761001 | 0.91 | TACR3 (0.71) | TACR3SPRCYP2C9CYP2C19HTR2B | |
| SCHEMBL31324479 | 0.88 | TACR3 (0.62) | HSD11B1TACR3SPRCARM1PRMT6 | |
| SCHEMBL22048483 | 0.85 | TACR3 (0.59) | HSD11B1TACR3SPRCARM1PRMT6 | |
| SCHEMBL14263092 | 0.85 | TACR3 (0.59) | HSD11B1TACR3CARM1PRMT6CYP2C9 | |
| SCHEMBL12794066 | 0.82 | HSD11B1 (0.56) | HSD11B1TACR3AGTR2CARM1PRMT6 | |
| SCHEMBL7419173 | 0.81 | CYP2C9 (0.65) | TACR3CYP2C9CYP2C19HTR2BMAPK14 | |
| SCHEMBL1760827 | 0.81 | KMT2A (0.54) | HSD11B1MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL7822101 | 0.81 | L3MBTL1 (0.60) | HSD11B1TACR3CARM1PRMT6CYP2C9 | |
| SCHEMBL8237687 | 0.79 | ACKR3 (0.57) | HSD11B1TACR3KDM4E | |
| SCHEMBL6214983 | 0.79 | ACKR3 (0.57) | HSD11B1TACR3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3505171-A1 | BICYCLIC NITROGENATED HETEROCYCLIC COMPOUND | Mitsubishi Tanabe Pharma Corporation (JP) | 2019-07-03 | — | — | EP | disclosed |
| US-20190185479-A1 | BICYCLIC NITROGENATED HETEROCYCLIC COMPOUND | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2019-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190185479-A1 | BICYCLIC NITROGENATED HETEROCYCLIC COMPOUND | PDE7B, PDE3A, PDE7A | HSD11B1 478/4885TACR3 1097/4885AGTR2 442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.