Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.47 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2226272 | 1.00 | TSHR (0.56) | TSHRSMN1; SMN2HPGDPOLBPKM | |
| SCHEMBL3810198 | 1.00 | TSHR (0.56) | TSHRSMN1; SMN2HPGDPOLBPKM | |
| Hydrochloric Acid SCHEMBL1226221 | 0.98 | TSHR (0.54) | TSHRSMN1; SMN2HPGDPOLBPKM | |
| SCHEMBL11158442 | 0.90 | TSHR (0.65) | TSHRSMN1; SMN2HPGDPOLBPKM | |
| SCHEMBL2687912 | 0.89 | HPGD (0.49) | TSHRSMN1; SMN2HPGDPOLBPKM | |
| SCHEMBL2688841 | 0.86 | ALDH1A1 (0.60) | TSHRHPGDHTTALDH1A1LMNA | |
| SCHEMBL14115754 | 0.85 | RECQL (0.47) | TSHRSMN1; SMN2HPGDPOLBPKM | |
| SCHEMBL2687790 | 0.85 | TSHR (0.56) | TSHRSMN1; SMN2HPGDPOLBPKM | |
| SCHEMBL2952742 | 0.82 | TSHR (0.57) | TSHRSMN1; SMN2HPGDPOLBPKM | |
| SCHEMBL3087287 | 0.82 | TSHR (0.57) | TSHRSMN1; SMN2HPGDPOLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3498701-A1 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme Inc (US) | 2019-06-19 | — | — | EP | disclosed |