Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 14/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SHBG | P04278 | 1/20 | 0.44 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.44 |
| ▸ | GUSB | P08236 | 1/20 | 0.44 |
| ▸ | G6PD | P11413 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2909333 | 1.00 | SRD5A2 (0.69) | SRD5A2CYP3A4CYP2C9CYP2C19TDP1 | |
| SCHEMBL9226234 | 0.89 | SRD5A2 (0.68) | SRD5A2CYP3A4ALDH1A1HSD17B10CYP19A1 | |
| SCHEMBL9226232 | 0.89 | SRD5A2 (0.68) | SRD5A2CYP3A4ALDH1A1HSD17B10CYP19A1 | |
| SCHEMBL17591557 | 0.84 | SRD5A2 (0.63) | SRD5A2CYP19A1 | |
| SCHEMBL17831186 | 0.84 | SRD5A2 (0.63) | SRD5A2CYP19A1 | |
| SCHEMBL15079264 | 0.84 | SRD5A2 (0.63) | SRD5A2CYP19A1 | |
| SCHEMBL6379452 | 0.84 | SRD5A2 (0.63) | SRD5A2CYP19A1 | |
| SCHEMBL11517545 | 0.82 | SRD5A2 (0.73) | SRD5A2CYP3A4CYP19A1MEN1LMNA | |
| SCHEMBL13217277 | 0.82 | SRD5A2 (0.47) | SRD5A2ALDH1A1HSD17B10CYP19A1SHBG | |
| SCHEMBL14199313 | 0.82 | SRD5A2 (0.50) | SRD5A2CYP3A4TDP1ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3909966-A1 | 19-NOR C3,3-DISUBSTITUTED C21-N-PYRAZOLYL STEROID FOR USE IN THERAPY | Sage Therapeutics, Inc. (US) | 2021-11-17 | — | — | EP | disclosed |
| EP-3498725-B1 | 19-NOR C3,3-DISUBSTITUTED C21-N-PYRAZOLYL STEROID FOR USE IN THERAPY | SAGE THERAPEUTICS INC (US) | 2021-06-09 | — | — | EP | disclosed |
| EP-3498725-A1 | 19-NOR C3,3-DISUBSTITUTED C21-N-PYRAZOLYL STEROID FOR USE IN THERAPY | Sage Therapeutics, Inc. (US) | 2019-06-19 | — | — | EP | disclosed |