Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 3/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.33 |
| ▸ | PNP | P00491 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21140874 | 0.88 | NT5E (0.33) | NT5E | |
| SCHEMBL21140873 | 0.88 | NT5E (0.33) | NT5E | |
| SCHEMBL21058098 | 0.87 | NT5E (0.34) | NT5EPRMT5WDR77PNPLMNA | |
| SCHEMBL19412739 | 0.84 | PNP (0.39) | NT5EPRMT5WDR77PNPLMNA | |
| SCHEMBL21141083 | 0.81 | NT5E (0.36) | NT5E | |
| SCHEMBL31003392 | 0.79 | NT5E (0.31) | NT5E | |
| SCHEMBL21140921 | 0.79 | NT5E (0.31) | NT5E | |
| SCHEMBL21058163 | 0.79 | NT5E (0.31) | NT5E | |
| SCHEMBL17106727 | 0.78 | NT5E (0.35) | NT5EPRMT5PNPLMNATP53 | |
| SCHEMBL31003351 | 0.78 | NT5E (0.39) | NT5EPRMT5SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190185508-A1 | DEUTERATED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2019-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190185508-A1 | DEUTERATED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | DUT, DIMT1, POLRMT | NT5E 1053/4885PRMT5 244/4885WDR77 998/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.