Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 7/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.35 |
| ▸ | IDH2 | P48735 | 2/20 | 0.34 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.32 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.32 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21144171 | 0.85 | KCNH2 (0.40) | LMNASMN1; SMN2KCNH2IDH1SCN9A | |
| SCHEMBL31127173 | 0.84 | KCNH2 (0.37) | LMNASMN1; SMN2KCNH2IDH1SCN9A | |
| SCHEMBL21144284 | 0.84 | KCNH2 (0.37) | LMNASMN1; SMN2KCNH2IDH1SCN9A | |
| SCHEMBL31127300 | 0.82 | KCNH2 (0.47) | KCNH2IDH1SCN9APTGS2IDH2 | |
| SCHEMBL21143837 | 0.82 | KCNH2 (0.47) | KCNH2IDH1SCN9APTGS2IDH2 | |
| SCHEMBL31127073 | 0.81 | GPR119 (0.36) | LMNASMN1; SMN2KCNH2IDH1SCN9A | |
| SCHEMBL21144088 | 0.81 | GPR119 (0.36) | LMNASMN1; SMN2KCNH2IDH1SCN9A | |
| SCHEMBL21143887 | 0.81 | PTGS2 (0.54) | LMNASMN1; SMN2KCNH2IDH1PTGS2 | |
| SCHEMBL21166208 | 0.79 | KCNH2 (0.33) | LMNASMN1; SMN2KCNH2IDH1SCN9A | |
| SCHEMBL31127190 | 0.79 | KCNH2 (0.33) | LMNASMN1; SMN2KCNH2IDH1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10774064-B2 | Potassium channel modulators | CADENT THERAPEUTICS, INC. (US) | 2020-09-15 | — | — | US | disclosed |
| US-10774064-B2 | Potassium channel modulators | CADENT THERAPEUTICS, INC. (US) | 2020-09-15 | — | — | US | disclosed |
| US-20190218200-A1 | POTASSIUM CHANNEL MODULATORS | NOVARTIS AG (CH) | 2019-07-18 | — | — | US | disclosed |
| US-20190218200-A1 | POTASSIUM CHANNEL MODULATORS | NOVARTIS AG (CH) | 2019-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10774064-B2 | Potassium channel modulators | KCNJ11, KCNJ2, KCNJ1 | LMNA 1529/4885SMN1; SMN2 1109/4885KCNH2 22/4885 |
| US-20190218200-A1 | POTASSIUM CHANNEL MODULATORS | KCNJ11, KCNJ2, KCNJ1 | LMNA 1529/4885SMN1; SMN2 1109/4885KCNH2 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.