Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 5/20 | 0.33 |
| ▸ | GSK3B | P49841 | 5/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 4/20 | 0.33 |
| ▸ | PAK4 | O96013 | 4/20 | 0.33 |
| ▸ | PRKACA | P17612 | 4/20 | 0.33 |
| ▸ | CDK8 | P49336 | 4/20 | 0.33 |
| ▸ | PRKX | P51817 | 4/20 | 0.33 |
| ▸ | MAP4K2 | Q12851 | 4/20 | 0.33 |
| ▸ | STK3 | Q13188 | 4/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.33 |
| ▸ | MELK | Q14680 | 4/20 | 0.33 |
| ▸ | MINK1 | Q8N4C8 | 4/20 | 0.33 |
| ▸ | HIPK2 | Q9H2X6 | 4/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.33 |
| ▸ | MAP4K5 | Q9Y4K4 | 4/20 | 0.33 |
| ▸ | CDK2 | P24941 | 4/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19686558 | 0.87 | IDH1 (0.47) | OPRK1MAPK8IDH1 | |
| SCHEMBL21143867 | 0.84 | KCNN3 (0.38) | OPRK1CDC7GSK3BDAPK3PAK4 | |
| SCHEMBL21143777 | 0.84 | PTGS2 (0.36) | OPRK1 | |
| SCHEMBL21165822 | 0.81 | PIK3CA (0.40) | MAPK1MEN1KMT2A | |
| SCHEMBL31127184 | 0.81 | PIM1 (0.42) | OPRK1CDC7GSK3BDAPK3PAK4 | |
| SCHEMBL21143902 | 0.81 | PIM1 (0.42) | OPRK1CDC7GSK3BDAPK3PAK4 | |
| SCHEMBL19686822 | 0.78 | IDH1 (0.47) | OPRK1CDK2CDK5IDH1CCNA2 | |
| SCHEMBL19687320 | 0.74 | IDH1 (0.47) | IDH1MEN1KMT2AKCNN2KCNN3 | |
| SCHEMBL19687162 | 0.73 | IDH1 (0.46) | MAPK8IDH1 | |
| SCHEMBL21143804 | 0.73 | PIM1 (0.43) | CDC7GSK3BDAPK3PAK4PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240317705-A1 | POTASSIUM CHANNEL MODULATORS | NOVARTIS AG (CH) | 2024-09-26 | — | — | US | disclosed |
| US-10774064-B2 | Potassium channel modulators | CADENT THERAPEUTICS, INC. (US) | 2020-09-15 | — | — | US | disclosed |
| US-10774064-B2 | Potassium channel modulators | CADENT THERAPEUTICS, INC. (US) | 2020-09-15 | — | — | US | disclosed |
| US-20190218200-A1 | POTASSIUM CHANNEL MODULATORS | NOVARTIS AG (CH) | 2019-07-18 | — | — | US | disclosed |
| US-20190218200-A1 | POTASSIUM CHANNEL MODULATORS | NOVARTIS AG (CH) | 2019-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240317705-A1 | POTASSIUM CHANNEL MODULATORS | KCNJ11, KCNJ2, KCNJ1 | OPRK1 337/4885CDC7 3353/4885GSK3B 2806/4885 |
| US-10774064-B2 | Potassium channel modulators | KCNJ11, KCNJ2, KCNJ1 | OPRK1 337/4885CDC7 3353/4885GSK3B 2806/4885 |
| US-20190218200-A1 | POTASSIUM CHANNEL MODULATORS | KCNJ11, KCNJ2, KCNJ1 | OPRK1 337/4885CDC7 3353/4885GSK3B 2806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.