Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methylprednisolone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 7/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 8/20 | 1.00 |
| ▸ | PGR | P06401 | 7/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 6/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 1/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 1/20 | 1.00 |
| ▸ | AR | P10275 | 3/20 | 0.79 |
| ▸ | F2 | P00734 | 1/20 | 0.79 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.70 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.70 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.70 |
| ▸ | TNF | P01375 | 1/20 | 0.70 |
| ▸ | IL6 | P05231 | 1/20 | 0.70 |
| ▸ | GLUL | P15104 | 1/20 | 0.70 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.70 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylprednisolone SCHEMBL16221544 | 1.00 | HIF1A (1.00) | HIF1APGRNR3C1CYP3A4HSD17B10 | |
| Methylprednisolone SCHEMBL5084 | 1.00 | HIF1A (1.00) | HIF1APGRNR3C1CYP3A4HSD17B10 | |
| Methylprednisolone SCHEMBL7160264 | 1.00 | HIF1A (1.00) | HIF1APGRNR3C1CYP3A4HSD17B10 | |
| Methylprednisolone SCHEMBL143076 | 1.00 | HIF1A (1.00) | HIF1APGRNR3C1CYP3A4HSD17B10 | |
| Methylprednisolone SCHEMBL5085 | 1.00 | HIF1A (1.00) | HIF1APGRNR3C1CYP3A4HSD17B10 | |
| Methylprednisolone SCHEMBL12440040 | 1.00 | HIF1A (1.00) | HIF1APGRNR3C1CYP3A4HSD17B10 | |
| Methylprednisolone SCHEMBL541256 | 1.00 | HIF1A (1.00) | HIF1APGRNR3C1CYP3A4HSD17B10 | |
| Methylprednisolone SCHEMBL13046609 | 1.00 | HIF1A (1.00) | HIF1APGRNR3C1CYP3A4HSD17B10 | |
| Methylprednisolone SCHEMBL13300483 | 1.00 | HIF1A (1.00) | HIF1APGRNR3C1CYP3A4HSD17B10 | |
| Methylprednisolone SCHEMBL193216 | 1.00 | HIF1A (1.00) | HIF1APGRNR3C1CYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190216823-A1 | METHYLPREDNISOLONE PHARMACEUTICAL SUSPENSION | HYLORIS DEVELOPMENTS SA (BE) | 2019-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190216823-A1 | METHYLPREDNISOLONE PHARMACEUTICAL SUSPENSION | NR3C1, MC2R, SERPINA6 | NR3C1 1/4885HIF1A 4217/4885PGR 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.