Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 12/20 | 0.38 |
| ▸ | KRAS | P01116 | 2/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2114702 | 1.00 | P2RX3 (0.38) | P2RX3KRASSOS1CYP2C9CYP1A2 | |
| SCHEMBL2114085 | 0.93 | OPRK1 (0.34) | P2RX3SOS1PIK3CDOPRK1AKT1 | |
| SCHEMBL2113805 | 0.92 | P2RX3 (0.34) | P2RX3KRASSOS1CYP2C9CYP1A2 | |
| SCHEMBL2115362 | 0.92 | OPRK1 (0.34) | P2RX3PIK3CDOPRK1AKT1 | |
| SCHEMBL2113554 | 0.91 | P2RX3 (0.35) | P2RX3PIK3CDOPRK1AKT1 | |
| SCHEMBL2113556 | 0.91 | P2RX3 (0.35) | P2RX3PIK3CDOPRK1AKT1 | |
| SCHEMBL2117052 | 0.91 | TP53 (0.35) | P2RX3SOS1PIK3CDOPRK1AKT1 | |
| SCHEMBL2117046 | 0.91 | TP53 (0.35) | P2RX3SOS1PIK3CDOPRK1AKT1 | |
| SCHEMBL2113700 | 0.91 | ABCB1 (0.36) | ABCG2OPRK1 | |
| SCHEMBL2113546 | 0.91 | KCNH2 (0.37) | P2RX3SOS1KCNH2OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120095005-A1 | Fused Bicyclic Pyrazole Derivatives As Kinase Inhibitors | UCB PHARMA S.A. (BE) | 2012-04-19 | — | — | US | claimed |
| US-20120095005-A1 | Fused Bicyclic Pyrazole Derivatives As Kinase Inhibitors | UCB PHARMA S.A. (BE) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095005-A1 | Fused Bicyclic Pyrazole Derivatives As Kinase Inhibitors | PI4KA, PDPK1, PIK3CA | P2RX3 123/4885KRAS 1096/4885SOS1 1776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.