Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | UBE2M | P61081 | 7/20 | 0.32 |
| ▸ | DCUN1D1 | Q96GG9 | 7/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25447572 | 0.89 | SIGMAR1 (0.46) | SIGMAR1OPRM1OPRL1MEN1KMT2A | |
| SCHEMBL14197719 | 0.88 | SIGMAR1 (0.37) | SIGMAR1OPRM1OPRL1MEN1POLB | |
| SCHEMBL19121468 | 0.85 | SIGMAR1 (0.36) | SIGMAR1MEN1KMT2ADPP4DPP8 | |
| SCHEMBL15018440 | 0.83 | SIGMAR1 (0.39) | SIGMAR1MEN1KMT2A | |
| SCHEMBL15092771 | 0.83 | SIGMAR1 (0.39) | SIGMAR1MEN1KMT2A | |
| SCHEMBL15092622 | 0.83 | SIGMAR1 (0.39) | SIGMAR1MEN1KMT2A | |
| SCHEMBL15096953 | 0.83 | SIGMAR1 (0.39) | SIGMAR1MEN1KMT2A | |
| SCHEMBL19121606 | 0.83 | OPRL1 (0.41) | SIGMAR1OPRM1OPRL1 | |
| SCHEMBL15019478 | 0.83 | SIGMAR1 (0.39) | SIGMAR1MEN1KMT2A | |
| SCHEMBL18256142 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458105-B1 | POLYNUCLEOTIDES ENCODING GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE FOR THE TREATMENT OF GALACTOSEMIA TYPE 1 | MODERNATX INC (US) | 2024-01-17 | — | — | EP | disclosed |
| EP-3896164-A1 | POLYNUCLEOTIDES ENCODING ALPHA-GALACTOSIDASE A FOR THE TREATMENT OF FABRY DISEASE | ModernaTX, Inc. (US) | 2021-10-20 | — | — | EP | disclosed |
| WO-2019136442-A1 | CD16A BINDING AGENTS AND USES THEREOF | KLEO PHARMACEUTICALS, INC. (US) | 2019-07-11 | — | — | WO | disclosed |