⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12125007 | 0.91 | HRH4 (0.31) | — | |
| SCHEMBL12125008 | 0.91 | HRH4 (0.31) | — | |
| SCHEMBL23903141 | 0.86 | DNM1 (0.32) | — | |
| SCHEMBL21150667 | 0.82 | SIGMAR1 (0.39) | — | |
| SCHEMBL12934878 | 0.79 | EBP (0.42) | — | |
| SCHEMBL12125041 | 0.79 | EBP (0.42) | — | |
| SCHEMBL12125040 | 0.79 | EBP (0.42) | — | |
| SCHEMBL25447572 | 0.79 | SIGMAR1 (0.46) | — | |
| SCHEMBL12934886 | 0.79 | EBP (0.42) | — | |
| SCHEMBL12934876 | 0.79 | EBP (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016184832-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | F. HOFFMANN-LA ROCHE AG (CH) | 2016-11-24 | — | — | WO | disclosed |