Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 18/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.45 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21154002 | 0.96 | FGFR4 (0.60) | FGFR4KDM4EALDH1A1SMN1; SMN2FGFR1 | |
| SCHEMBL15412791 | 0.90 | FGFR4 (0.69) | FGFR4KDM4EALDH1A1SMN1; SMN2FGFR1 | |
| SCHEMBL29385382 | 0.90 | FGFR4 (0.69) | FGFR4KDM4EALDH1A1SMN1; SMN2FGFR1 | |
| SCHEMBL19943152 | 0.89 | KDM4E (0.47) | FGFR4KDM4EALDH1A1SMN1; SMN2FGFR1 | |
| SCHEMBL22781316 | 0.86 | FGFR4 (0.52) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 | |
| SCHEMBL21153921 | 0.85 | FGFR4 (0.60) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 | |
| SCHEMBL19943434 | 0.83 | LCK (0.53) | FGFR4 | |
| SCHEMBL21153337 | 0.83 | FGFR4 (0.57) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 | |
| SCHEMBL21154011 | 0.81 | FGFR4 (0.55) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 | |
| SCHEMBL27746938 | 0.81 | KDM4E (0.64) | FGFR4KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3508482-B1 | INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR AND USE THEREOF | NANJING TRANSTHERA BIOSCIENCES CO LTD (CN) | 2020-12-16 | — | — | EP | disclosed |
| EP-3508482-A1 | INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR AND USE THEREOF | Nanjing Transthera Biosciences Co. Ltd. (CN) | 2019-07-10 | — | — | EP | disclosed |