Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 15/20 | 0.53 |
| ▸ | KDR | P35968 | 8/20 | 0.53 |
| ▸ | JAK3 | P52333 | 2/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
| ▸ | KIT | P10721 | 14/20 | 0.53 |
| ▸ | SRC | P12931 | 14/20 | 0.53 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21153337 | 0.94 | FGFR4 (0.57) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL21153989 | 0.89 | LCK (0.47) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL16676911 | 0.88 | FGFR4 (0.66) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL22781316 | 0.86 | FGFR4 (0.52) | LCKKITSRCFGFR4 | |
| SCHEMBL5489026 | 0.84 | LCK (0.55) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL21154059 | 0.83 | FGFR4 (0.56) | FGFR4 | |
| SCHEMBL21153647 | 0.80 | FGFR4 (0.54) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL21154002 | 0.80 | FGFR4 (0.60) | FGFR4 | |
| SCHEMBL21153921 | 0.80 | FGFR4 (0.60) | FGFR4 | |
| SCHEMBL22781190 | 0.80 | FGFR4 (0.56) | LCKKITSRCFGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3508482-B1 | INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR AND USE THEREOF | NANJING TRANSTHERA BIOSCIENCES CO LTD (CN) | 2020-12-16 | — | — | EP | disclosed |
| EP-3508482-A1 | INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR AND USE THEREOF | Nanjing Transthera Biosciences Co. Ltd. (CN) | 2019-07-10 | — | — | EP | disclosed |
| WO-2018040885-A1 | INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR AND USE THEREOF | 南京药捷安康生物科技有限公司 | 2018-03-08 | — | — | WO | disclosed |