Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 14/20 | 0.57 |
| ▸ | LCK | P06239 | 6/20 | 0.48 |
| ▸ | KIT | P10721 | 5/20 | 0.48 |
| ▸ | SRC | P12931 | 5/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.48 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19943434 | 0.94 | LCK (0.53) | FGFR4LCKKITSRCKDR | |
| SCHEMBL16676911 | 0.92 | FGFR4 (0.66) | FGFR4LCKKITSRCKDR | |
| SCHEMBL21153921 | 0.88 | FGFR4 (0.60) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 | |
| SCHEMBL21154002 | 0.88 | FGFR4 (0.60) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 | |
| SCHEMBL21153647 | 0.85 | FGFR4 (0.54) | FGFR4LCKKITSRCKDR | |
| SCHEMBL22781190 | 0.84 | FGFR4 (0.56) | FGFR4LCKKITSRCFGFR1 | |
| SCHEMBL21154011 | 0.83 | FGFR4 (0.55) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 | |
| SCHEMBL21153989 | 0.83 | LCK (0.47) | FGFR4LCKKITSRCKDR | |
| SCHEMBL21154059 | 0.83 | FGFR4 (0.56) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 | |
| SCHEMBL21153914 | 0.82 | FGFR4 (0.51) | FGFR4LCKKITSRCKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3508482-B1 | INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR AND USE THEREOF | NANJING TRANSTHERA BIOSCIENCES CO LTD (CN) | 2020-12-16 | — | — | EP | disclosed |
| EP-3508482-A1 | INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR AND USE THEREOF | Nanjing Transthera Biosciences Co. Ltd. (CN) | 2019-07-10 | — | — | EP | disclosed |