Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 3/20 | 0.59 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CFTR | P13569 | 1/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.46 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.46 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21153987 | 0.91 | BAZ2B (0.47) | BAZ2BBRD3ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL21588367 | 0.90 | BAZ2B (0.58) | BAZ2BBRD3ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL5104575 | 0.90 | BAZ2B (0.71) | BAZ2BBRD3ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL10127727 | 0.88 | BAZ2B (0.62) | BAZ2BBRD3ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL30228645 | 0.87 | TRPV1 (0.57) | BAZ2BSMN1; SMN2LMNAPABPC1ATM | |
| SCHEMBL21154472 | 0.85 | BAZ2B (0.61) | BAZ2BALOX15TSHRHSD17B10CFTR | |
| SCHEMBL30228476 | 0.85 | BAZ2B (0.61) | BAZ2BALOX15TSHRHSD17B10CFTR | |
| SCHEMBL11670023 | 0.84 | SMN1; SMN2 (0.63) | BAZ2BALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL21154454 | 0.83 | LMNA (0.55) | BAZ2BMAPTMEN1KMT2ALMNA | |
| SCHEMBL31117582 | 0.82 | BAZ2B (0.60) | BAZ2BALDH1A1SMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3735411-B1 | 1,3,4,5-TETRAHYDRO-2H-PYRIDO[4,3-B]INDOLE DERIVATIVES FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES LIKE ALZHEIMER`S DISEASE | AC IMMUNE SA (CH) | 2024-07-10 | — | — | EP | disclosed |
| WO-2019134978-A1 | 1, 3, 4, 5-TETRAHYDRO-2H-PYRIDO[4,3-B]INDOLE DERIVATIVES FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES LIKE ALZHEIMER'S DISEASE | AC IMMUNE SA (CH) | 2019-07-11 | — | — | WO | disclosed |