Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.61 |
| ▸ | KDR | P35968 | 3/20 | 0.59 |
| ▸ | CFTR | P13569 | 9/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30228476 | 1.00 | BAZ2B (0.61) | BAZ2BKDRCFTRCYP1A2CYP2D6 | |
| SCHEMBL21154494 | 0.91 | BAZ2B (0.50) | BAZ2BKDRCFTRCYP1A2CYP2C9 | |
| SCHEMBL21588257 | 0.90 | BAZ2B (0.61) | BAZ2BKDRCFTRCYP1A2CYP2D6 | |
| SCHEMBL30228575 | 0.90 | BAZ2B (0.74) | BAZ2BKDRCFTRCYP1A2CYP2D6 | |
| SCHEMBL21162488 | 0.90 | BAZ2B (0.74) | BAZ2BKDRCFTRCYP1A2CYP2D6 | |
| SCHEMBL30228645 | 0.86 | TRPV1 (0.57) | BAZ2BLMNATRPV1 | |
| SCHEMBL21154458 | 0.85 | BAZ2B (0.59) | BAZ2BCFTRALOX15HSD17B10LMNA | |
| SCHEMBL30667631 | 0.82 | BAZ2B (0.49) | BAZ2BKDRCFTRCYP1A2CYP2D6 | |
| SCHEMBL31117446 | 0.82 | BAZ2B (0.62) | BAZ2BKDRCFTRCYP1A2CYP2D6 | |
| SCHEMBL21154454 | 0.82 | LMNA (0.55) | BAZ2BLMNATRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3735411-B1 | 1,3,4,5-TETRAHYDRO-2H-PYRIDO[4,3-B]INDOLE DERIVATIVES FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES LIKE ALZHEIMER`S DISEASE | AC IMMUNE SA (CH) | 2024-07-10 | — | — | EP | disclosed |
| CN-111196806-B | Guanidine derivative and application thereof | 广东东阳光药业股份有限公司 | 2024-04-26 | — | — | CN | disclosed |
| CN-109928971-B | Aryl substituted aminotetrahydropyrans and uses thereof | 广东东阳光药业股份有限公司 | 2024-01-16 | — | — | CN | disclosed |
| WO-2019134978-A1 | 1, 3, 4, 5-TETRAHYDRO-2H-PYRIDO[4,3-B]INDOLE DERIVATIVES FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES LIKE ALZHEIMER'S DISEASE | AC IMMUNE SA (CH) | 2019-07-11 | — | — | WO | disclosed |