Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KCNH3 | Q9ULD8 | 2/20 | 0.38 |
| ▸ | GBA1 | P04062 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16840853 | 0.80 | JAK2 (0.58) | JAK2JAK3KDM4EGAAALDH1A1 | |
| SCHEMBL16840469 | 0.74 | JAK2 (0.64) | JAK2JAK3KDM4EGAAALDH1A1 | |
| SCHEMBL29974262 | 0.73 | ALDH1A1 (0.42) | JAK2RECQLMCL1KDM4EMAPK1 | |
| SCHEMBL2640343 | 0.71 | JAK2 (1.00) | JAK2JAK3KDM4EMAPK1GAA | |
| SCHEMBL30496382 | 0.71 | JAK2 (0.55) | JAK2JAK3LMNA | |
| SCHEMBL2717765 | 0.70 | JAK2 (0.46) | JAK2JAK3KDM4EGAAALDH1A1 | |
| SCHEMBL17131652 | 0.70 | JAK2 (0.58) | JAK2JAK3KDM4EGAAALDH1A1 | |
| SCHEMBL11413826 | 0.69 | PDE10A (0.44) | JAK2JAK3KDM4EGAAALDH1A1 | |
| SCHEMBL4061727 | 0.69 | JAK2 (0.56) | JAK2JAK3KDM4EMAPK1GAA | |
| SCHEMBL5300653 | 0.67 | JAK2 (0.50) | JAK2JAK3KDM4EGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019134978-A1 | 1, 3, 4, 5-TETRAHYDRO-2H-PYRIDO[4,3-B]INDOLE DERIVATIVES FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES LIKE ALZHEIMER'S DISEASE | AC IMMUNE SA (CH) | 2019-07-11 | — | — | WO | disclosed |