Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | CFTR | P13569 | 6/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 3/20 | 0.43 |
| ▸ | CDK4 | P11802 | 2/20 | 0.42 |
| ▸ | CCND1 | P24385 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21154472 | 0.91 | BAZ2B (0.61) | BAZ2BKDRCFTRTRPV1CYP1A2 | |
| SCHEMBL30228476 | 0.91 | BAZ2B (0.61) | BAZ2BKDRCFTRTRPV1CYP1A2 | |
| SCHEMBL21114768 | 0.90 | BAZ2B (0.61) | BAZ2BKDRADRA2AADRA2BADRA2C | |
| SCHEMBL30506408 | 0.90 | BAZ2B (0.61) | BAZ2BKDRADRA2AADRA2BADRA2C | |
| SCHEMBL21153987 | 0.85 | BAZ2B (0.47) | BAZ2BADRA1ACFTRTRPV1CDK4 | |
| SCHEMBL21154454 | 0.82 | LMNA (0.55) | BAZ2BTRPV1CDK4CCND1 | |
| SCHEMBL21162488 | 0.81 | BAZ2B (0.74) | BAZ2BKDRCFTRCYP1A2CYP2C9 | |
| SCHEMBL30228575 | 0.81 | BAZ2B (0.74) | BAZ2BKDRCFTRCYP1A2CYP2C9 | |
| SCHEMBL21588257 | 0.81 | BAZ2B (0.61) | BAZ2BKDRCFTRTRPV1CDK4 | |
| SCHEMBL30228645 | 0.79 | TRPV1 (0.57) | BAZ2BTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019134978-A1 | 1, 3, 4, 5-TETRAHYDRO-2H-PYRIDO[4,3-B]INDOLE DERIVATIVES FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES LIKE ALZHEIMER'S DISEASE | AC IMMUNE SA (CH) | 2019-07-11 | — | — | WO | disclosed |