Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.48 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 7/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21155432 | 0.90 | POLB (0.42) | POLBNCOA1NCOA3ALDH1A1MAPT | |
| SCHEMBL21155164 | 0.89 | POLB (0.41) | POLBNCOA1NCOA3ALDH1A1MAPT | |
| SCHEMBL21155177 | 0.81 | POLB (0.43) | POLBNCOA1NCOA3ALDH1A1MAPT | |
| SCHEMBL18042332 | 0.80 | ALDH1A1 (0.55) | POLBNCOA1NCOA3ALDH1A1MAPT | |
| SCHEMBL17997972 | 0.73 | PDE10A (0.73) | POLBALDH1A1MAPTL3MBTL1TSHR | |
| SCHEMBL16582329 | 0.73 | ALDH1A1 (0.63) | ALDH1A1MAPTL3MBTL1CYP1A2MEN1 | |
| SCHEMBL18748158 | 0.71 | PDE10A (0.65) | POLBALDH1A1MAPTL3MBTL1TSHR | |
| SCHEMBL19051828 | 0.71 | MAPT (0.71) | POLBALDH1A1MAPTL3MBTL1CYP1A2 | |
| SCHEMBL16546996 | 0.71 | MAPT (0.67) | POLBALDH1A1MAPTL3MBTL1CYP1A2 | |
| SCHEMBL21155161 | 0.71 | MAPT (0.45) | POLBALDH1A1MAPTL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512848-B1 | COMPOUNDS WITH CARBAZOLE STRUCTURES | MERCK PATENT GMBH (DE) | 2020-11-18 | — | — | EP | disclosed |
| US-20190214574-A1 | COMPOUNDS WITH CARBAZOLE STRUCTURES | MERCK PATENT GMBH (DE) | 2019-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190214574-A1 | COMPOUNDS WITH CARBAZOLE STRUCTURES | CYCS, CYP3A4, CYP2E1 | POLB 1544/4885NCOA1 1431/4885NCOA3 242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.