Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.66 |
| ▸ | TLK2 | Q86UE8 | 2/20 | 0.66 |
| ▸ | KIT | P10721 | 3/20 | 0.55 |
| ▸ | EGFR | P00533 | 2/20 | 0.55 |
| ▸ | NEK2 | P51955 | 2/20 | 0.55 |
| ▸ | MELK | Q14680 | 1/20 | 0.55 |
| ▸ | MET | P08581 | 6/20 | 0.54 |
| ▸ | FLT3 | P36888 | 5/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.52 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13755234 | 1.00 | KDR (0.66) | KDRPDGFRBFGFR1TLK2KIT | |
| SCHEMBL6427814 | 0.88 | KDR (0.65) | KDRPDGFRBFGFR1TLK2KIT | |
| SCHEMBL2116509 | 0.88 | KDR (0.65) | KDRPDGFRBFGFR1TLK2KIT | |
| SCHEMBL142633 | 0.88 | KDR (0.66) | KDRPDGFRBFGFR1TLK2KIT | |
| SCHEMBL6082409 | 0.87 | KDR (0.74) | KDRPDGFRBFGFR1TLK2KIT | |
| SCHEMBL31672505 | 0.87 | KDR (0.74) | KDRPDGFRBFGFR1TLK2KIT | |
| SCHEMBL2116563 | 0.87 | KDR (0.74) | KDRPDGFRBFGFR1TLK2KIT | |
| SCHEMBL13755252 | 0.86 | KDR (0.81) | KDRPDGFRBFGFR1TLK2KIT | |
| SCHEMBL4474309 | 0.85 | ALK (0.58) | KDRPDGFRBFGFR1KITEGFR | |
| SCHEMBL3720888 | 0.85 | ALK (0.58) | KDRPDGFRBFGFR1KITEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094998-A1 | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates | NEKTAR THERAPEUTICS (US) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094998-A1 | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates | PTK2B, ERBB2, FRK | KDR 395/4885PDGFRB 555/4885FGFR1 462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.