Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.65 |
| ▸ | PDGFRB | P09619 | 11/20 | 0.65 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.65 |
| ▸ | TLK2 | Q86UE8 | 2/20 | 0.65 |
| ▸ | FLT3 | P36888 | 5/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.54 |
| ▸ | MET | P08581 | 3/20 | 0.54 |
| ▸ | PRKAA1 | Q13131 | 6/20 | 0.49 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.49 |
| ▸ | LCK | P06239 | 3/20 | 0.49 |
| ▸ | KIT | P10721 | 3/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 2/20 | 0.48 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.48 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6427814 | 1.00 | KDR (0.65) | KDRPDGFRBFGFR1TLK2FLT3 | |
| SCHEMBL13755234 | 0.88 | KDR (0.66) | KDRPDGFRBFGFR1TLK2FLT3 | |
| SCHEMBL2115618 | 0.88 | KDR (0.66) | KDRPDGFRBFGFR1TLK2FLT3 | |
| SCHEMBL3800332 | 0.85 | ALK (0.57) | KDRPDGFRBFGFR1FLT3AURKB | |
| SCHEMBL3801277 | 0.85 | ALK (0.57) | KDRPDGFRBFGFR1FLT3AURKB | |
| SCHEMBL31672500 | 0.83 | KDR (0.74) | KDRPDGFRBFGFR1TLK2FLT3 | |
| SCHEMBL2114225 | 0.83 | KDR (0.74) | KDRPDGFRBFGFR1TLK2FLT3 | |
| SCHEMBL13755241 | 0.83 | KDR (0.74) | KDRPDGFRBFGFR1TLK2FLT3 | |
| SCHEMBL140610 | 0.82 | KDR (0.70) | KDRPDGFRBFGFR1TLK2FLT3 | |
| SCHEMBL13755236 | 0.81 | KDR (0.65) | KDRPDGFRBFGFR1TLK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3789027-A1 | BOSUTINIB, SUNITINIB, TIVOZANIB, IMATINIB, NILOTINIB, REBASTINIB OR BAFETINIB FOR PREVENTING AND/OR TREATING AMYOTROPHIC LATERAL SCLEROSIS | KYOTO UNIVERSITY (JP) | 2021-03-10 | — | — | EP | disclosed |
| US-20120094998-A1 | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates | NEKTAR THERAPEUTICS (US) | 2012-04-19 | — | — | US | disclosed |
| US-7125905-B2 | Pyrrole substituted 2-indolinone protein kinase inhibitors | AGOURON PHARMACEUTICALS, INC. (US) | 2006-10-24 | — | — | US | disclosed |
| US-20050176802-A1 | Pyrrole substituted 2-indolinone protein kinase inhibitors | SUGEN, INC. & PHARMACIA & UPJOHN CO. | 2005-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176802-A1 | Pyrrole substituted 2-indolinone protein kinase inhibitors | PDPK1, MAP3K20, PLK2 | KDR 1372/4885PDGFRB 974/4885FGFR1 1091/4885 |
| US-20120094998-A1 | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates | PTK2B, ERBB2, FRK | KDR 395/4885PDGFRB 555/4885FGFR1 462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.