Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS11D | O60235 | 2/20 | 0.63 |
| ▸ | CTRL | P40313 | 2/20 | 0.63 |
| ▸ | PSMB5 | P28074 | 14/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.62 |
| ▸ | CYP3A7 | P24462 | 2/20 | 0.62 |
| ▸ | CYP3A43 | Q9HB55 | 2/20 | 0.62 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.62 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.62 |
| ▸ | PSMB10 | P40306 | 2/20 | 0.62 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.62 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.62 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.62 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.62 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.62 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.62 |
| ▸ | PSMD3 | O43242 | 1/20 | 0.62 |
| ▸ | CTSB | P07858 | 1/20 | 0.62 |
| ▸ | PSMC3 | P17980 | 1/20 | 0.62 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8266994 | 0.94 | CTRL (0.71) | TMPRSS11DCTRLPSMB5CYP3A4CYP3A5 | |
| SCHEMBL20284864 | 0.94 | CTRL (0.71) | TMPRSS11DCTRLPSMB5CYP3A4CYP3A5 | |
| SCHEMBL20000632 | 0.94 | CTRL (0.71) | TMPRSS11DCTRLPSMB5CYP3A4CYP3A5 | |
| SCHEMBL21367439 | 0.89 | TMPRSS11D (0.65) | TMPRSS11DCTRLPSMB5CYP3A4CYP3A5 | |
| SCHEMBL19474555 | 0.88 | TMPRSS11D (0.70) | TMPRSS11DCTRLPSMB5CYP3A4CYP3A5 | |
| SCHEMBL16254118 | 0.85 | CTRL (0.59) | TMPRSS11DCTRLPSMB5CYP3A4CYP3A5 | |
| SCHEMBL20825471 | 0.85 | TMPRSS11D (0.66) | TMPRSS11DCTRLPSMB5CYP3A4CYP3A5 | |
| SCHEMBL23616283 | 0.85 | TMPRSS11D (0.76) | TMPRSS11DCTRLPSMB5CYP3A4CYP3A5 | |
| SCHEMBL21229438 | 0.85 | TMPRSS11D (0.76) | TMPRSS11DCTRLPSMB5CYP3A4CYP3A5 | |
| SCHEMBL17629503 | 0.85 | TMPRSS11D (0.76) | TMPRSS11DCTRLPSMB5CYP3A4CYP3A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190211058-A1 | COMPOUNDS FOR PROTEASOME ENZYME INHIBITION | PROTEOLIX, INC. | 2019-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190211058-A1 | COMPOUNDS FOR PROTEASOME ENZYME INHIBITION | PSMB1, PSMB9, PSMB3 | TMPRSS11D 338/4885CTRL 43/4885PSMB5 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.