Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 9/20 | 0.53 |
| ▸ | KDR | P35968 | 9/20 | 0.51 |
| ▸ | FLT3 | P36888 | 5/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.47 |
| ▸ | CSF1R | P07333 | 3/20 | 0.47 |
| ▸ | PLK4 | O00444 | 2/20 | 0.47 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.47 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.47 |
| ▸ | INSR | P06213 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | FYN | P06241 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31216363 | 0.84 | KDR (0.71) | AKT2KDRFLT3PRKAA1PDPK1 | |
| SCHEMBL13755275 | 0.80 | KDR (0.73) | AKT2KDRFLT3PRKAA1PDPK1 | |
| SCHEMBL2114561 | 0.78 | PAK4 (0.57) | AKT2KDRFLT3PRKAA1PDPK1 | |
| SCHEMBL30454529 | 0.78 | PDPK1 (0.60) | AKT2KDRFLT3PDPK1NTRK1 | |
| SCHEMBL3799498 | 0.77 | AKT2 (0.67) | AKT2KDRFLT3PDPK1NTRK1 | |
| SCHEMBL14864981 | 0.70 | FLT3 (0.63) | AKT2KDRFLT3PRKAA1PDPK1 | |
| SCHEMBL5727779 | 0.70 | AKT2 (1.00) | AKT2PDPK1PDK1 | |
| SCHEMBL5727776 | 0.70 | AKT2 (1.00) | AKT2PDPK1PDK1 | |
| SCHEMBL5518067 | 0.69 | KDR (0.77) | AKT2KDRFLT3PRKAA1PDPK1 | |
| SCHEMBL13711983 | 0.69 | KDR (0.77) | AKT2KDRFLT3PRKAA1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094998-A1 | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates | NEKTAR THERAPEUTICS (US) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094998-A1 | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates | PTK2B, ERBB2, FRK | AKT2 500/4885KDR 395/4885FLT3 111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.