Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TEAD1 | P28347 | 4/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.38 |
| ▸ | SELE | P16581 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875489 | 0.80 | AR (0.53) | EPAS1TTRSMN1; SMN2ARL3MBTL1 | |
| SCHEMBL875278 | 0.80 | EPAS1 (0.55) | EPAS1TTRSMN1; SMN2ARL3MBTL1 | |
| SCHEMBL875557 | 0.80 | EPAS1 (0.52) | EPAS1TTRSMN1; SMN2ARL3MBTL1 | |
| SCHEMBL883499 | 0.80 | EPAS1 (0.49) | EPAS1TTRSMN1; SMN2ARL3MBTL1 | |
| SCHEMBL875580 | 0.79 | FFAR1 (0.51) | EPAS1TTREGFRERBB2ERBB3 | |
| SCHEMBL876331 | 0.79 | EPAS1 (0.48) | EPAS1TTRSMN1; SMN2ARL3MBTL1 | |
| SCHEMBL15278007 | 0.78 | EPAS1 (0.47) | EPAS1TTRSMN1; SMN2ARL3MBTL1 | |
| SCHEMBL11195440 | 0.76 | PRKCA (0.50) | EPAS1SMN1; SMN2L3MBTL1ALDH1A1POLB | |
| SCHEMBL21731439 | 0.76 | EPAS1 (0.48) | EPAS1TTRSMN1; SMN2ARL3MBTL1 | |
| SCHEMBL875627 | 0.76 | AR (0.57) | EPAS1SMN1; SMN2ARPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3172211-B1 | TRICYCLIC IMIDAZO-PYRIMIDINONE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY LP-PLA2 | GLAXOSMITHKLINE IP DEV LTD (GB) | 2019-07-03 | — | — | EP | disclosed |