Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 4/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16237821 | 0.89 | TP53 (0.49) | HPGDSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL27828485 | 0.81 | CYP1A2 (0.47) | L3MBTL1LMNAHPGDCYP1A2CYP2C19 | |
| SCHEMBL15151310 | 0.80 | CYP2A6 (0.45) | L3MBTL1HPGDALDH1A1 | |
| SCHEMBL13996229 | 0.79 | L3MBTL1 (0.56) | L3MBTL1LMNAHPGDCYP1A2CYP2C19 | |
| SCHEMBL725346 | 0.78 | TRPV1 (0.46) | L3MBTL1HPGDALDH1A1 | |
| SCHEMBL111861 | 0.77 | L3MBTL1 (0.64) | L3MBTL1LMNAHPGDCYP1A2CYP2C19 | |
| SCHEMBL5030948 | 0.77 | CYP1A2 (0.60) | L3MBTL1LMNAHPGDCYP1A2CYP2C19 | |
| SCHEMBL27806372 | 0.77 | ALDH1A1 (0.50) | L3MBTL1HPGDALDH1A1TSHR | |
| SCHEMBL16237057 | 0.77 | SYK (0.48) | HPGDSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL12267358 | 0.76 | CYP2A6 (0.50) | ROCK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2555755-B2 | PHARMACEUTICAL COMPOSITIONS OF 3-(6-(1-(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL) CYCLOPROPANECARBOXAMIDO)-3-METHYLPYRIODIN-2-YL)BENZOIC ACID AND ADMINISTRATION THEREOF | VERTEX PHARMA (US) | 2019-07-10 | — | — | EP | disclosed |
| CN-103864678-A | PROCESSES FOR PRODUCING CYCLOALKYLCARBOXIAMIDO-PYRIDINE BENZOIC ACIDS | VERTEX PHARMA | 2014-06-18 | — | — | CN | disclosed |
| CN-101910134-B | Process for the production of cycloalkylcarboxamido-pyridine benzoic acids | VERTEX PHARMA | 2014-03-19 | — | — | CN | disclosed |
| CN-103626744-A | Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid | VERTEX PHARMA | 2014-03-12 | — | — | CN | disclosed |
| CN-101910156-B | Solid forms of 3- (6- (1- (2, 2-difluorobenzo [ D ] [1,3] dioxol-5-yl) cyclopropanecarboxamido) -3-methylpyridin-2-yl) benzoic acid | VERTEX PHARMA | 2013-12-04 | — | — | CN | disclosed |
| CN-101910134-A | Process for the production of cycloalkylcarboxamido-pyridine benzoic acids | VERTEX PHARMA | 2010-12-08 | — | — | CN | disclosed |
| CN-101910156-A | Solid forms of 3- (6- (1- (2, 2-difluorobenzo [ D ] [1,3] dioxol-5-yl) cyclopropanecarboxamido) -3-methylpyridin-2-yl) benzoic acid | VERTEX PHARMA | 2010-12-08 | — | — | CN | disclosed |