Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.36 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29571670 | 0.85 | HTR2A (0.39) | HTR2AHTR2CHTTSMARCA4PBRM1 | |
| SCHEMBL29571431 | 0.85 | CDK9 (0.43) | HTTDYRK1ACDK2ADORA2A | |
| SCHEMBL18202323 | 0.85 | HTR2A (0.39) | HTR2AHTR2CHTTSMARCA4PBRM1 | |
| SCHEMBL18202270 | 0.81 | HTR2A (0.40) | HTR2AHTR2CTHRBTGFBR1MAPK14 | |
| SCHEMBL19930265 | 0.81 | HRH1 (0.34) | HTR2CTHRBTGFBR1MAPK14 | |
| SCHEMBL19966896 | 0.78 | EIF2AK2 (0.39) | THRBTGFBR1MAPK14EIF2AK2 | |
| SCHEMBL18911634 | 0.72 | HTR2A (0.37) | HTR2AHTR2CSMARCA4PBRM1 | |
| SCHEMBL12604657 | 0.72 | HTR2A (0.64) | HTR2AHTR2CSMARCA4PBRM1 | |
| SCHEMBL1104626 | 0.67 | HTR2A (0.66) | HTR2AHTR2C | |
| SCHEMBL30749787 | 0.67 | HTR2A (0.66) | HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3312179-B1 | FUSED-RING OR TRICYCLIC ARYL PYRIMIDINE COMPOUND USED AS KINASE INHIBITOR | NANJING SANHOME PHARMACEUTICAL CO LTD (CN) | 2019-07-10 | — | — | EP | disclosed |