Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 11/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.33 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.32 |
| ▸ | CDK2 | P24941 | 3/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21138374 | 0.99 | HSD11B1 (0.35) | HSD11B1NR1I2ADORA3YTHDC1IDO1 | |
| SCHEMBL21057270 | 0.85 | ADORA3 (0.44) | ADORA3 | |
| SCHEMBL21057273 | 0.85 | ADORA3 (0.44) | ADORA3 | |
| SCHEMBL21138331 | 0.84 | HSD11B1 (0.47) | HSD11B1NR1I2ADORA3CCNE1CDK2 | |
| SCHEMBL21138816 | 0.83 | HSD11B1 (0.49) | HSD11B1NR1I2ADORA3CCNE1CDK2 | |
| SCHEMBL21138249 | 0.83 | HSD11B1 (0.45) | HSD11B1NR1I2ADORA3CCNE1CDK2 | |
| SCHEMBL21138894 | 0.81 | HSD11B1 (0.34) | HSD11B1 | |
| SCHEMBL19917049 | 0.80 | HSD11B1 (0.37) | HSD11B1NR1I2ADORA3CCNE1CDK2 | |
| SCHEMBL21057446 | 0.80 | HSD11B1 (0.37) | HSD11B1NR1I2ADORA3CCNE1CDK2 | |
| SCHEMBL30396230 | 0.80 | HSD11B1 (0.37) | HSD11B1NR1I2ADORA3CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3505171-A1 | BICYCLIC NITROGENATED HETEROCYCLIC COMPOUND | Mitsubishi Tanabe Pharma Corporation (JP) | 2019-07-03 | — | — | EP | disclosed |