Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 4/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 4/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.40 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21138850 | 0.85 | EGFR (0.50) | JAK2JAK1GPR119SRCEGFR | |
| SCHEMBL21138453 | 0.85 | EGFR (0.50) | JAK2JAK1GPR119SRCEGFR | |
| SCHEMBL21138452 | 0.85 | EGFR (0.50) | JAK2JAK1GPR119SRCEGFR | |
| SCHEMBL21159459 | 0.81 | GPR119 (0.46) | JAK2JAK1GPR119SRCEGFR | |
| SCHEMBL21138227 | 0.81 | GPR119 (0.46) | JAK2JAK1GPR119SRCEGFR | |
| SCHEMBL21138499 | 0.81 | GPR119 (0.46) | JAK2JAK1GPR119SRCEGFR | |
| SCHEMBL22009062 | 0.73 | JAK2 (0.48) | JAK2JAK1SRCEGFRFPR2 | |
| SCHEMBL21903722 | 0.73 | JAK2 (0.48) | JAK2JAK1SRCEGFRFPR2 | |
| SCHEMBL21579420 | 0.73 | EGFR (0.48) | JAK2SRCEGFRBTKPIK3CD | |
| SCHEMBL6274546 | 0.73 | EGFR (0.48) | JAK2SRCEGFRBTKPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3505171-A1 | BICYCLIC NITROGENATED HETEROCYCLIC COMPOUND | Mitsubishi Tanabe Pharma Corporation (JP) | 2019-07-03 | — | — | EP | disclosed |