Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 14/20 | 0.34 |
| ▸ | JAK1 | P23458 | 11/20 | 0.34 |
| ▸ | JAK2 | O60674 | 8/20 | 0.33 |
| ▸ | TYK2 | P29597 | 6/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21159366 | 0.82 | JAK3 (0.49) | MAP4K4JAK3JAK1JAK2TYK2 | |
| SCHEMBL21159272 | 0.79 | JAK3 (0.42) | MAP4K4JAK3JAK1JAK2MEN1 | |
| SCHEMBL19916990 | 0.79 | JAK3 (0.42) | MAP4K4JAK3JAK1JAK2MEN1 | |
| SCHEMBL21159280 | 0.78 | JAK1 (0.37) | JAK3JAK1JAK2TYK2MEN1 | |
| SCHEMBL21159353 | 0.76 | JAK3 (0.34) | JAK3JAK1JAK2TYK2MEN1 | |
| SCHEMBL21159292 | 0.76 | JAK3 (0.33) | JAK3JAK1JAK2TYK2MEN1 | |
| SCHEMBL21159572 | 0.76 | MAP4K4 (0.36) | MAP4K4JAK3JAK1JAK2TYK2 | |
| SCHEMBL19917011 | 0.76 | MAP4K4 (0.36) | MAP4K4JAK3JAK1JAK2TYK2 | |
| SCHEMBL21159571 | 0.74 | JAK3 (0.46) | JAK3JAK1JAK2MEN1KMT2A | |
| SCHEMBL19917086 | 0.73 | JAK3 (0.34) | JAK3JAK1JAK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3505171-A1 | BICYCLIC NITROGENATED HETEROCYCLIC COMPOUND | Mitsubishi Tanabe Pharma Corporation (JP) | 2019-07-03 | — | — | EP | disclosed |