Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 9/20 | 0.34 |
| ▸ | JAK2 | O60674 | 6/20 | 0.34 |
| ▸ | TYK2 | P29597 | 5/20 | 0.34 |
| ▸ | JAK1 | P23458 | 8/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21159572 | 0.86 | MAP4K4 (0.36) | JAK3JAK2TYK2JAK1MEN1 | |
| SCHEMBL21159280 | 0.86 | JAK1 (0.37) | JAK3JAK2TYK2JAK1MEN1 | |
| SCHEMBL21159272 | 0.79 | JAK3 (0.42) | JAK3JAK2JAK1MEN1KMT2A | |
| SCHEMBL19916990 | 0.79 | JAK3 (0.42) | JAK3JAK2JAK1MEN1KMT2A | |
| SCHEMBL21159366 | 0.79 | JAK3 (0.49) | JAK3JAK2TYK2JAK1MEN1 | |
| SCHEMBL19917011 | 0.78 | MAP4K4 (0.36) | JAK3JAK2TYK2JAK1MEN1 | |
| SCHEMBL21159292 | 0.78 | JAK3 (0.33) | JAK3JAK2TYK2JAK1MEN1 | |
| SCHEMBL21159262 | 0.76 | MAP4K4 (0.36) | JAK3JAK2TYK2JAK1MEN1 | |
| SCHEMBL21159582 | 0.71 | JAK2 (0.35) | JAK3JAK2TYK2JAK1 | |
| SCHEMBL21159570 | 0.71 | JAK2 (0.37) | JAK3JAK2JAK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3505171-A1 | BICYCLIC NITROGENATED HETEROCYCLIC COMPOUND | Mitsubishi Tanabe Pharma Corporation (JP) | 2019-07-03 | — | — | EP | disclosed |