Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 10/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 6/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.30 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21159571 | 0.83 | JAK3 (0.46) | JAK3MEN1KMT2AJAK1CYP3A4 | |
| SCHEMBL21159272 | 0.83 | JAK3 (0.42) | JAK3MEN1KMT2AJAK1CYP3A4 | |
| SCHEMBL19916990 | 0.83 | JAK3 (0.42) | JAK3MEN1KMT2AJAK1CYP3A4 | |
| SCHEMBL21159280 | 0.82 | JAK1 (0.37) | JAK3MEN1KMT2AJAK1JAK2 | |
| SCHEMBL21159262 | 0.82 | MAP4K4 (0.36) | JAK3MEN1KMT2AJAK1CYP3A4 | |
| SCHEMBL21159292 | 0.79 | JAK3 (0.33) | JAK3MEN1KMT2AJAK1CYP3A4 | |
| SCHEMBL21159109 | 0.79 | PAK1 (0.35) | JAK3JAK1 | |
| SCHEMBL21159572 | 0.79 | MAP4K4 (0.36) | JAK3MEN1KMT2AJAK1CYP3A4 | |
| SCHEMBL21159353 | 0.79 | JAK3 (0.34) | JAK3MEN1KMT2AJAK1CYP3A4 | |
| SCHEMBL19917011 | 0.79 | MAP4K4 (0.36) | JAK3MEN1KMT2AJAK1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3505171-A1 | BICYCLIC NITROGENATED HETEROCYCLIC COMPOUND | Mitsubishi Tanabe Pharma Corporation (JP) | 2019-07-03 | — | — | EP | disclosed |