Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | ROS1 | P08922 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | FER | P16591 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | MARK3 | P27448 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21159294 | 0.84 | HTT (0.36) | JAK2MAP4K4CDC7PLK4DYRK3 | |
| SCHEMBL21159571 | 0.84 | JAK3 (0.46) | JAK2LCKLIMK1JAK1JAK3 | |
| SCHEMBL21159272 | 0.83 | JAK3 (0.42) | JAK2MAP4K4JAK1JAK3MEN1 | |
| SCHEMBL21159582 | 0.78 | JAK2 (0.35) | JAK2RETJAK1JAK3DGAT1 | |
| SCHEMBL21159366 | 0.74 | JAK3 (0.49) | JAK2MAP4K4LIMK1JAK1JAK3 | |
| SCHEMBL21159572 | 0.74 | MAP4K4 (0.36) | JAK2MAP4K4JAK1JAK3MEN1 | |
| SCHEMBL21159292 | 0.71 | JAK3 (0.33) | JAK2JAK1JAK3MEN1CYP3A4 | |
| SCHEMBL19917086 | 0.71 | JAK3 (0.34) | JAK2JAK1JAK3MEN1CYP3A4 | |
| SCHEMBL21159280 | 0.71 | JAK1 (0.37) | JAK2JAK1JAK3MEN1KMT2A | |
| SCHEMBL21159370 | 0.68 | JAK3 (0.40) | JAK2JAK1JAK3HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3505171-A1 | BICYCLIC NITROGENATED HETEROCYCLIC COMPOUND | Mitsubishi Tanabe Pharma Corporation (JP) | 2019-07-03 | — | — | EP | disclosed |