Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | WDR5 | P61964 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.31 |
| ▸ | JAK1 | P23458 | 6/20 | 0.31 |
| ▸ | JAK3 | P52333 | 4/20 | 0.31 |
| ▸ | JAK2 | O60674 | 4/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21138178 | 0.78 | IRAK1 (0.41) | LMNAKMT2AWDR5JAK3 | |
| SCHEMBL21159370 | 0.77 | JAK3 (0.40) | LMNAKMT2AMEN1HSD11B1JAK1 | |
| SCHEMBL21159294 | 0.72 | HTT (0.36) | KMT2AWDR5JAK1JAK3JAK2 | |
| SCHEMBL14165369 | 0.68 | IRAK1 (0.41) | LMNA | |
| SCHEMBL14165368 | 0.68 | IRAK1 (0.41) | LMNA | |
| SCHEMBL29740638 | 0.68 | IRAK1 (0.41) | LMNA | |
| SCHEMBL14165818 | 0.68 | IRAK1 (0.41) | LMNA | |
| SCHEMBL14165782 | 0.68 | IRAK1 (0.41) | LMNA | |
| SCHEMBL14165965 | 0.68 | IRAK1 (0.41) | LMNA | |
| SCHEMBL21159262 | 0.68 | MAP4K4 (0.36) | KMT2AMEN1JAK1JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3505171-A1 | BICYCLIC NITROGENATED HETEROCYCLIC COMPOUND | Mitsubishi Tanabe Pharma Corporation (JP) | 2019-07-03 | — | — | EP | disclosed |