Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL633803 | 1.00 | HRH3 (0.36) | HRH3KCNH2RECQLGAAHPGD | |
| SCHEMBL18768680 | 1.00 | HRH3 (0.36) | HRH3KCNH2RECQLGAAHPGD | |
| SCHEMBL6496552 | 1.00 | HRH3 (0.36) | HRH3KCNH2RECQLGAAHPGD | |
| SCHEMBL19649547 | 0.98 | RECQL (0.38) | HRH3KCNH2RECQLGAAHPGD | |
| SCHEMBL16627509 | 0.98 | RECQL (0.38) | HRH3KCNH2RECQLGAAHPGD | |
| SCHEMBL10996925 | 0.97 | HRH3 (0.36) | HRH3KCNH2GAAHPGDALDH1A1 | |
| SCHEMBL7021706 | 0.95 | HRH3 (0.35) | HRH3KCNH2RECQLGAAHPGD | |
| SCHEMBL16254919 | 0.95 | HRH3 (0.35) | HRH3KCNH2RECQLGAAHPGD | |
| SCHEMBL30341037 | 0.95 | HRH3 (0.35) | HRH3KCNH2RECQLGAAHPGD | |
| SCHEMBL5872327 | 0.95 | HRH3 (0.38) | HRH3KCNH2RECQLGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3505519-A1 | PYRIDINAMINE-SUBSTITUTED HETEROTRICYCLO COMPOUNDS, PREPARATION THEREOF, AND USE IN MEDICINES | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. (CN) | 2019-07-03 | — | — | EP | disclosed |