Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11002232 | 0.97 | HRH3 (0.39) | HRH3KCNH2 | |
| SCHEMBL21160967 | 0.95 | HRH3 (0.36) | HRH3KCNH2RECQLALDH1A1SMN1; SMN2 | |
| SCHEMBL633803 | 0.95 | HRH3 (0.36) | HRH3KCNH2RECQLALDH1A1SMN1; SMN2 | |
| SCHEMBL6496552 | 0.95 | HRH3 (0.36) | HRH3KCNH2RECQLALDH1A1SMN1; SMN2 | |
| SCHEMBL18768680 | 0.95 | HRH3 (0.36) | HRH3KCNH2RECQLALDH1A1SMN1; SMN2 | |
| SCHEMBL19649547 | 0.93 | RECQL (0.38) | HRH3KCNH2RECQLALDH1A1SMN1; SMN2 | |
| SCHEMBL16627509 | 0.93 | RECQL (0.38) | HRH3KCNH2RECQLALDH1A1SMN1; SMN2 | |
| SCHEMBL10862757 | 0.92 | HRH3 (0.39) | HRH3KCNH2 | |
| SCHEMBL20413253 | 0.92 | HRH3 (0.39) | HRH3KCNH2 | |
| SCHEMBL13544683 | 0.92 | HRH3 (0.39) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |
| US-8629157-B2 | Pyrrolidine compounds which modulate the CB2 receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-01-14 | — | — | US | disclosed |
| US-7649011-B2 | Active against cancer proliferation, growth, and metastasis; such as 3,4,5-trimethoxy-n-(2-methyl-3-phenyl-allyl)-n-[2-(1-methyl-pyrrolidin-2-yl)-thyl]-benzamide; side effect reduction | CHEMOCENTRYX, INC. (US) | 2010-01-19 | — | — | US | disclosed |
| CN-1764377-A | Utilize aryl and alkyl nitro compounds reductive amination of lactones to prepare the method for N-aryl-2-lactam and N-alkyl-2-lactam | DU PONT (US) | 2006-04-26 | — | — | CN | disclosed |
| US-6991744-B2 | Refrigerant compositions containing a compatibilizer | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2006-01-31 | — | — | US | disclosed |
| US-4534978-A | OXYGEN CARRYING COMPONENTS; TRANSFUSIONS | THE GREEN CROSS CORPORATION (JP) | 1985-08-13 | — | — | US | disclosed |