Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 14/20 | 0.56 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24590990 | 0.89 | MET (0.44) | METFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL24591041 | 0.88 | MET (0.53) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL24591117 | 0.87 | MET (0.53) | METPAK1KEAP1F2PRSS1 | |
| SCHEMBL24590995 | 0.87 | MET (0.41) | METPAK1KEAP1F2PRSS1 | |
| SCHEMBL21167404 | 0.86 | MET (0.58) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL22475667 | 0.86 | MET (0.57) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL24591049 | 0.83 | MET (0.41) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL24591043 | 0.83 | MET (0.54) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL22475713 | 0.82 | MET (0.53) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL24591054 | 0.81 | MET (0.57) | METPDE3BPDE3ACYP2C9PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795573-B1 | CERTAIN TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | HUTCHISON MEDIPHARMA LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |