Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 11/20 | 0.58 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | LDHB | P07195 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21167480 | 0.91 | MET (0.47) | METCSF1RLDHALDHBKEAP1 | |
| SCHEMBL22475667 | 0.90 | MET (0.57) | METCSF1RKEAP1CYP2C9PDE3B | |
| SCHEMBL24591043 | 0.89 | MET (0.54) | METKEAP1IKBKETBK1CYP2C9 | |
| SCHEMBL22475658 | 0.89 | CSF1R (0.46) | METCSF1RLDHALDHBKEAP1 | |
| SCHEMBL24590985 | 0.88 | MET (0.46) | METCSF1RIKBKETBK1TYRO3 | |
| SCHEMBL21167421 | 0.87 | CSF1R (0.59) | METCSF1RLDHALDHBKEAP1 | |
| SCHEMBL21167403 | 0.86 | MET (0.56) | METKEAP1CYP2C9PDE3BPDE3A | |
| SCHEMBL24590986 | 0.86 | MET (0.59) | METCSF1RLDHALDHBKEAP1 | |
| SCHEMBL22475927 | 0.86 | MET (0.43) | METCSF1RLDHALDHBKEAP1 | |
| SCHEMBL22475713 | 0.86 | MET (0.53) | METKEAP1IKBKETBK1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795573-B1 | CERTAIN TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | HUTCHISON MEDIPHARMA LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |