Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 7/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.37 |
| ▸ | LDHB | P07195 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22475658 | 0.93 | CSF1R (0.46) | METCSF1RMAPK1KEAP1LDHA | |
| SCHEMBL21167404 | 0.91 | MET (0.58) | METCSF1RKEAP1LDHALDHB | |
| SCHEMBL24590985 | 0.90 | MET (0.46) | METCSF1RTYRO3SYKPIK3CD | |
| SCHEMBL22475990 | 0.90 | MET (0.47) | METCSF1RMAPK1NAMPTKEAP1 | |
| SCHEMBL21167421 | 0.89 | CSF1R (0.59) | METCSF1RMAPK1KEAP1LDHA | |
| SCHEMBL24590986 | 0.86 | MET (0.59) | METCSF1RNAMPTKEAP1LDHA | |
| SCHEMBL22475927 | 0.86 | MET (0.43) | METCSF1RKEAP1LDHALDHB | |
| SCHEMBL23128064 | 0.85 | MET (0.44) | METCSF1RMAPK1NAMPTKEAP1 | |
| SCHEMBL21167673 | 0.84 | CSF1R (0.45) | METCSF1RMAPK1NAMPTKEAP1 | |
| SCHEMBL21167380 | 0.82 | DYRK1A (0.44) | METCSF1RNAMPTKEAP1LDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |